Phosphoinositide phosphatases and disease
نویسندگان
چکیده
منابع مشابه
Regulating Glut4 vesicle dynamics by phosphoinositide kinases and phosphoinositide phosphatases.
Phosphorylated derivatives of phosphatydylinositol (PtdIns), collectively called phosphoinositides (PIs), have been recognized as versatile second messengers and modulators of lipid membrane composition in all eukaryotes. Over the last several years, PIs emerged as key membrane-localized signals for regulating a myriad of cellular processes, including insulin-induced membrane receptor signaling...
متن کاملBiochemistry and structure of phosphoinositide phosphatases
Phosphoinositides are the phosphorylated derivatives of phosphatidylinositol, and play a very significant role in a diverse range of signaling processes in eukaryotic cells. A number of phosphoinositide-metabolizing enzymes, including phosphoinositide-kinases and phosphatases are involved in the synthesis and degradation of these phospholipids. Recently, the function of various phosphatases in ...
متن کاملPhosphoinositide phosphatases: emerging roles as voltage sensors?
During a genomic survey of the transparent sea squirt (Ciona intestinalis), Murata et al. discovered a gene that encodes a protein containing homologous sequences to both a CX(5)R phosphatase and an ion channel. The authors named the novel protein, C. intestinalis voltage-sensor-containing phosphatase, Ci-VSP. The N terminus of Ci-VSP appears to function as a voltage-gated sensor; the C terminu...
متن کاملRegulation of phosphoinositide signaling by the inositol polyphosphate 5-phosphatases.
Phosphoinositide signaling molecules control cellular growth, proliferation and differentiation, intracellular vesicle trafficking, and cytoskeletal rearrangement. The inositol polyphosphate 5-phosphatase family remove the D-5 position phosphate from PtdIns(3,4,5)P3, PtdIns(4,5)P2 and PtdIns(3,5)P2 forming PtdIns(3,4)P2, PtdIns(4)P and PtdIns(3)P respectively. This enzyme family, comprising ten...
متن کاملVoltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence.
Voltage-sensitive phosphatases (VSPs) are unique proteins in which membrane potential controls enzyme activity. They are comprised of the voltage sensor domain of an ion channel coupled to a lipid phosphatase specific for phosphoinositides, and for ascidian and zebrafish VSPs, the phosphatase activity has been found to be activated by membrane depolarization. The physiological functions of thes...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2009
ISSN: 0022-2275
DOI: 10.1194/jlr.r800072-jlr200